Health-disease Process of Acute Chagas Disease According to One Health Approach

Victor Viana da Graça *

State University of Pará, Perebebuí Avenue, 2623, Marco, 66087-662 Belém, Pará, Brazil.

Juarez Antônio Simões Quaresma

State University of Pará, Perebebuí Avenue, 2623, Marco, 66087-662 Belém, Pará, Brazil.

*Author to whom correspondence should be addressed.


One Health approach emerges as an innovative perspective to understand the health-disease process of acute Chagas disease (ACD). This study aimed to identify scientific evidence on the health-disease process of ACD through one health approach. This integrative literature review study had as guiding question: what is the current scientific evidence on the health-disease process of ACD according to One Health approach? A greater number of studies can be seen from 2021. The following categories were defined from the 13 studies found: One Health approach to Chagas disease; Spatial epidemiology of Chagas disease; Control and transmission factors of Chagas disease; Health indicators in Chagas disease; and Educational technology in Chagas disease. The results of this literature review, while showing greater proportions of studies involving ACD control and transmission, also demonstrate fields of study that are still little explored by national and international scientific literature, such as in the field of technologies for ACD, reflecting a large gap to be filled with future research on ACD. This study contributed to expanding the debate on the importance of an integrative approach in health research and encouraging the search for more comprehensive solutions for ACD.

Keywords: Chagas disease, one health, health-disease process

How to Cite

Graça, V. V. da, & Quaresma , J. A. S. (2024). Health-disease Process of Acute Chagas Disease According to One Health Approach. Archives of Current Research International, 24(5), 84–97.


Download data is not yet available.


Heukelbach J, Sousa AS, Ramos ANJ. New contributions to the elimination of chagas disease as a public health problem: Towards the Sustainable Development Goals by 2030. Trop. Med. Infect. Dis. 2021;6:23.

Pereira-Silva FS, Mello MLBC de, Araújo-Jorge TC de. Chagas disease: Facing invisibility by analyzing the life stories of chronic sufferers. Ciênc Saúde Colectivo. 2022;27(5):1939–49.

Sinclair Jr. Importance of a one health approach in advancing global health security and the sustainable development goals. Rev Sci Tech. 2019;38(1):145-154.

Fei SW, Xu JS, Lü S, Guo XK, Zhou XN. One health: Re-thinking of zoonoses control]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2022;34(1):1-6.

Pitt SJ, Gunn A. The one health concept. Br J Biomed Sci. 2024;81:12366.

Quaresma PF, Martins-Duarte ES, Soares Medeiros LC. Editorial: One health approach in zoonosis: Strategies to control, diagnose and treat neglected diseases. Front. Cell Infect. Microbiol. 2023;8(13):1227865.

Shaheen MNF. The concept of one health applied to the problem of zoonotic diseases. Rev Med Virol. 2022;32(4): e2326.

Lopez-García A, Juan AG. Oral transmission of chagas disease from a one health approach: A systematic review. Trop Med Int Health. 2023;1–10.

Galvão MCB, Ricarte ILM. Systematic literature review: Conceptualization, production and publication. Logeion: Philosophy of Information. 2020;6(1):57-73.

Sousa LMM, Marques-Vieira CMA, Severino SSP, Antunes AV. The methodology of integrative review of nursing literature. Journal of Nursing Research. 2017;21(2):17-26.

Bardin L. Content analysis. 1.ed. São Paulo: Editions. 2011;70.

Little SE. Future challenges for parasitology: vector control and one health in the Americas. Veterinary Parasitology. 2013;195(3-4):249-55.’

Case BKM, Young JG, Penados D, Monroy C, He´bert-Dufresne L, Stevens L. Spatial epidemiology and adaptive targeted sampling to manage the Chagas disease vector Triatoma dimidiata. PLoS Negl. Trop. Dis. 2022;16(6):e0010436.

Schurer JM, Mosites E, Li C, Meschke S, Rabinowitz P. Community-based surveillance of zoonotic parasites in a ‘One Health’ world: A systematic review. One Health. 2016;166–174.

Velázquez-Ramírez DD, Pérez de Léon AA, Ochoa-Díaz-López H. Review of American trypanosomiasis in Southern Mexico highlights opportunity for surveillance research to Advance control through the one health approach. Front. Public Health. 2022;10:838949.

Garcia MN, O’Day S, Fisher-Hoch S, Gorchakov R, Patino R, Feria Arroyo TP, et al. One health interactions of chagas disease vectors, canid hosts, and human residents along the texas-Mexico border. PLoS Negl. Trop. Dis. 2016;10(11): e0005074.

Francis S, Frank C, Buchanan L, Green S, Stennett-Brown R, Gordon-Strachan G, et al. Challenges in the control of neglected insect vector diseases of human importance in the Anglo-Caribbean. One Health. 2021;24(13):100316.

Martín-Escolano J, Marín C, Rosales MJ, Tsaousis AD, Medina-Carmona E, Martín-Escolano R. An updated view of the trypanosoma cruzi life cycle: Intervention points for an effective treatment. ACS Infectious Diseases. 2022;8(6):1107-1115.

Martínez-Parra AG, Pinilla-Alfonso MY, Abadía-Barrero CE. Sociocultural dynamics that influence Chagas disease health care in Colombia. Social Science & Medicine. 2018;215:142-150.

Taylor E, Aguilar-Ancori EG, Banyard AC, Abel I, Mantini-Briggs C, Briggs CL, et al. The amazonian tropical bites research initiative, a hope for resolving neglected zoonotic tropical diseases in the one health era. International Health. 2023;15(2):216-223.

Lanza FC, Ribeiro-Jr G, Miranda DLP, Santos FLN, Carvalho CMM, Cunha GM, et al. Epidemiological indicators of chagas disease in the metropolitan region of Salvador, Bahia, Brazil. Journal of the Brazilian Society of Tropical Medicine. 2023;56:e0185-2022.’

Araujo-Jorge TC, Ferreira RR, Rocha RCM, Vieira TM, Costa ND, Santos LL, et al. Chagas express XXI: A new ArtScience social technology for health and science education—A case study in Brazilian endemic areas of Chagas disease with an active search of chronic cases. PLoS Negl. Trop. Dis. 2021;15(7):e0009534.

Rachel EB, Sarah AH. Annual review of animal biosciences chagas disease ecology in the United States: Recent advances in understanding trypanosoma cruzi transmission among triatomines, wildlife, and domestic animals and a quantitative synthesis of vector–host interactions. Annu. Rev. Anim. Biosci. 2022;10:325–48.