Minireview of Stereoselective Brain Imaging
Donald F. Smith *
Institute for Clinical Research, Translational Neuropsychiatry Unit, Psychiatric Hospital of Aarhus University, Skovagervej 2 8240 Risskov, Denmark.
Steen Jakobsen
PET Center, Aarhus University Hospital, Noerrebrogade 4 8000 C Aarhus, Denmark.
*Author to whom correspondence should be addressed.
Abstract
Stereoselectivity is a fundamental principle in living systems. Stereoselectivity reflects the dependence of molecular processes on the spatial orientation of constituent atoms. Stereoselective processes govern many aspects of brain function and direct the course of many psychotropic drugs. Today, modern imaging techniques such as SPECT and PET provide a means for studying stereoselective processes in the living brain. Chemists have prepared numerous radiolabelled stereoisomers for use in SPECT and PET in order to explore various molecular processes in the living brain of anesthetized laboratory animals and awake humans. The studies have demonstrated how many aspects of neurotransmission consist of crucial stereoselective events that can affect brain function in health and disease. Here, we present a brief account of those findings in hope of stimulating further interest in the vital topic.
Keywords: Brain imaging, neurotransmission, neuroreceptors, stereoisomers, SPECT, PET