Archives of Current Research International

This study investigates the phytochemical composition, antioxidant, and antibacterial potential of extracts from Thottea siliquosa, a plant used in traditional medicine. A preliminary phytochemical screening of the plant material revealed the presence of alkaloids, flavonoids, tannins, phenols, saponins, and terpenoids, which are known bioactive compounds. The antioxidant capacity of the extracts was comprehensively evaluated using multiple in vitro assays, including DPPH, ABTS, FRAP, nitric oxide, and superoxide radical scavenging models. The results demonstrated significant and dose-dependent antioxidant activity across all tests, with the extracts showing a potent ability to neutralize free radicals and reduce oxidative stress. This strong antioxidant effect is likely attributable to the high concentration of phenolic and flavonoid compounds identified in the initial screening. Concurrently, the antibacterial efficacy was tested against a panel of Gram-positive (Streptococcus aureus, Bacillus thuringiensis) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacterial strains. The extracts exhibited notable antibacterial action, with varying degrees of inhibition observed against the tested pathogens. The findings collectively suggest that Thottea siliquosa is a rich source of natural antioxidants and antimicrobial agents. This validates its ethnomedicinal use and highlights its potential as a candidate for developing novel phytopharmaceuticals for managing oxidative stress-related diseases and bacterial infections.